2^nd World Congress on Polycystic Ovarian Syndrome October 05-06, 2016 Orlando, Florida, USA

Biography:

Debasis Bagchi, PhD, MACN, CNS, MAIChE, is the Chief Scientific Officer at Cepham Research Center, Piscataway, NJ; a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and, an Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of R&D of InterHealth Nutraceuticals Inc, CA, from 1998 till Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, till June 2013. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS). Dr. Bagchi is a Member of the Study Section and Peer Review Committee of NIH, Bethesda, MD. Dr. Bagchi has 315 papers in peer reviewed journals, 27 books and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences and Fellow of the Nutrition Research

Abstract:

Polycystic ovary syndrome (PCOS) is the most prevalent hormonal disorder among women of reproductive age causing irregular menstrual cycles, excessive body or facial hair, miscarriage and infertility. Infertility is one of most common PCOS symptoms. Because the symptoms of PCOS are seemingly unrelated to one another, the condition is often overlooked and undiagnosed. We conducted an open label, one-arm, non-randomized, post-marketing surveillance study in 50 premenopausal women (18-45 years, BMI<42) diagnosed with PCOS using a novel fenugreek seed extract (Furocyst, 2 capsules of 500 mg each/day) over a period of 90 consecutive days to determine its efficacy on the reduction of ovarian volume and the number of ovarian cysts. Ethical committee approval was obtained for this study. Furocyst caused significant reduction in ovary volume. Approximately 46% of study population showed reduction in cyst size, while 36% of subjects showed complete dissolution of cyst. It is important to mention that 71% of subjects reported regular menstrual cycle on completion of the treatment and 12% of subjects got pregnant. Overall, 94% of patients were benefitted from this study. Significant increases in luteinizing hormone (LH) and follicular stimulating hormone (FSH) levels were observed compared to the baseline values. Extensive blood chemistry, hematological and biochemical assays demonstrated the broad spectrum safety. Furocyst caused significant decrease in both ovarian volume and the number of ovarian cysts. In summary, Furocyst was safe and efficacious in ameliorating PCOS

Biography:

Dr. Ninive Sanchez is an Assistant Professor of Social Work at the University of Missouri-Columbia, College of Human Environmental Sciences.  Dr. Sanchez earned her PhD in Social Work and Psychology from the University of Michigan.  Her research interests are in the areas of health disparities, sociodeterminants of health, and chronic disease among low socioeconomic status and racial/ethnic minority groups

Abstract:

According to the 2012 National Institutes of Health Evidence-based Methodology Workshop on Polycystic Ovary Syndrome, there is a need to improve public awareness of polycystic ovary syndrome (PCOS).  In the United States, people increasingly look to the Internet to find out what medical condition they or someone else might have.  Women’s digital magazines are a type of “edutainment” that publish health content in addition to beauty, fashion, and entertainment content.  These media have the potential to expose primarily women readers to information on PCOS.  This presentation will present content on PCOS-related hirsutism published in women’s digital magazines such as Cosmopolitan en Español, O, The Oprah Magazine, Prevention, Women’s Health, Health, and Redbook.  This includes descriptions of hirsutism, information on PCOS symptoms and consequences (e.g., infertility), and advice to consult health care providers.  Examples of how women’s magazines appeal to readers’ concerns with hair growth and then provide readers with hair removal strategies and product advertisements to achieve smooth faces and bodies will also be presented.  The limited content on racial/ethnic differences in hirsutism and information on campaigns to raise awareness of PCOS and support women with PCOS will be noted.  Implications of the potential effects that content in women’s digital magazines can have on readers’ perceptions of PCOS-related hirsutism and the effect that women’s hair removal techniques can have on health care providers’ assessment of hirsutism will be discussed.

Biography:

Currently, Dr. Donaldson is the Director of the Clinical Processing Specimen Laboratory and the Director of the CLIA Laboratory in the Institute for Personalized Medicine at Penn State University where he is an assistant professor of biochemistry and molecular biology at the Penn State College of Medicine, and Milton S. Hershey Medical Center. Dr. Donaldson is also the founder and CEO of Prescient Medicine, where his work includes predictive disease modeling, preconditional drug response determination, and system failure point analysis and avoidance. He got his MD from Temple University School of Medicine and his MSCE from the University of Pennsylvania.

Abstract:

Polycystic ovary syndrome (PCOS) affects 5-7% of reproductive-age women. PCOS is characterized by increased androgen levels, anovulation, insulin insensitivity and infertility. Despite the high prevalence, there is no single specific test to definitively diagnose PCOS, representing an unmet diagnostic need. Previous studies  have identified DENND1A, a clathrin-binding protein that sits in coated pits at the crossroads of receptor/ligand interactions with downstream intracellular signaling pathways, as a strong PCOS candidate gene. We have shown that the truncated isoform of DENND1A (DENN1A.V2) is increased in ovarian theca cells isolated from PCOS women.  Forced overexpression of DENND1A.V2 in theca cells from normal cycling women resulted in a PCOS phenotype of increased androgen biosynthesis. We previously described the development and performance characteristics of a urine assay for the detection of DENN1A.V2 in exosomes and total RNA isolated from the blood and urine utilizing standard real-time quantitative PCR.  We are in the process of developing and automating high-throughput urine RNA isolation coupled inline with a semi-quantitative allele specific microarray based analytic. This assay will allow for rapid reproducible diagnosis of PCOS leading to precision therapeutics.

Biography:

The search for an effective treatment protocol for patients with PCOS provides us with the opportunity to integrate Eastern and Western medicine. Western medicine offers us diagnostic tools and technologies, allowing us to see the structures of the body from the organ systems all the way down to cells and molecules. TCM is based on a holistic view of healthcare, which takes into account a person’s mind, emotions, habits and diet, all of which affect the energetic function of the body. Acupuncture modality focuses on the improvement of this function by improving the flow of Qi, blood and fluid, while herbal formulae and nutrition help to strengthen the structure. PCOS has been recognized and treated by TCM for thousands of years. It falls under the Zheng Jia category of disorder, which pertains to “masses created by stagnation of fluid, blood, and/or Qi.” Depending on the individual’s constitution and her environment, she may present with different symptoms. For example, one patient may have blood stagnation, manifesting as endometriosis, while another may have fluid stagnation, manifesting as cysts. Hormone therapies might provide a temporary boost, but they do not correct the problem at its source. TCM treatment is infinitely flexible: the meridian points and herbs chosen will vary day to day, based on changes in the menstrual cycle, life events, and physical environment. The goal is not only to manage symptoms, but to also correct the imbalances on a deeper level, and to prevent the problem from returning in the future

Abstract:

At the heart of Dr. Cai’s practices are her holistic approach to healing and her belief in the collaborative relationship of patient and doctor. From 1986 to 1997, Dr Cai practiced and taught at Chengdu University's TCM Hospital, a major teaching hospital in China that specializes in integrating Eastern and Western medicine. Dr. Cai first worked there as a gynecologist and then as a senior and chief physician overseeing new residents. In 1997, Dr. Cai moved to Santa Monica, CA, where she opened her own acupuncture clinic in 2007. In her more than 25 years of practice as a doctor of TCM, Dr. Cai has published numerous papers, and her research with a former colleague in China is still relied on as a remedy for treating uterine fibroid tumors.

Biography:

Felix Day is a career development fellow in the Growth and Development programme at the Medical Research Council Epidemiology Unit, University of Cambridge, UK, where he also did his PhD. Before moving to Cambridge, he studied at the University of Oxford, UK, and the London School of Hygiene and Tropical Medicine, UK. His research interests include the links between reproductive phenotypes and disease, particularly metabolic disorders. This research includes using methods in both genetics and epidemiology to understand causality in these conditions.

Abstract:

Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in women, yet there is little consensus regarding its aetiology. Here we perform a genome-wide association study of PCOS in up to 5,184 self-reported cases of White European ancestry and 82,759 controls, with follow-up in a further ~2,000 clinically validated cases and ~100,000 controls. We identify six signals for PCOS at genome-wide statistical significance (P<5 × 10−8), in/near genes ERBB4/HER4, YAP1, THADA, FSHB, RAD50 and KRR1. Variants in/near three of the four epidermal growth factor receptor genes (ERBB2/HER2, ERBB3/HER3 and ERBB4/HER4) are associated with PCOS at or near genome-wide significance. Mendelian randomization analyses indicate causal roles in PCOS aetiology for higher BMI (P=2.5 × 10−9), higher insulin resistance (P=6 × 10−4) and lower serum sex hormone binding globulin concentrations (P=5 × 10−4). Furthermore, genetic susceptibility to later menopause is associated with higher PCOS risk (P=1.6 × 10−8) and PCOS-susceptibility alleles are associated with higher serum anti-Müllerian hormone concentrations in girls (P=8.9 × 10−5). This large-scale study implicates an aetiological role of the epidermal growth factor receptors, infers causal mechanisms relevant to clinical management and prevention, and suggests balancing selection mechanisms involved in PCOS risk.

Biography:

The polycystic ovary syndrome (PCOS) accounts for approximately 80% of women with anovulatory infertility. Various factors influence ovarian function and fertility is adversely affected by an individual being overweight, the degree of hyperandrogenism and having elevated serum concentrations of LH. Interestingly, a Finnish study showed that whilst women with PCOS may take longer to conceive but their lifetime fertility is not impaired and they may display sustained fertility with advancing age as compared with infertile eumenorrheic women. For those who do present with anovulatory infertility, the principles of therapy are first to optimize health before commencing treatment and then induce regular unifollicular ovulation, whilst minimizing the risks of OHSS and multiple pregnancy. Weight loss, in those who are overweight, should improve the endocrine profile, the likelihood of ovulation and a healthy pregnancy and the response to ovulation induction therapy. Anovulation associated with PCOS has long been known to be amenable to surgical treatment, and a long-term cohort study has shown persistence of ovulation and normalisation of serum androgens and SHBG up to 20 years after laparoscopic ovarian electrocautery in over 60% of subjects, particularly if they have a normal BMI

There is interesting new data on improved efficacy using aromatase inhibitors compared with CC. In vitro fertilization (IVF) may be required for women with anovulatory PCOS who do not conceive with ovulation induction or if there are other fertility factors such as tubal damage or male factors.

The effect of basal serum LH and LH/FSH ratio on outcomes of in vitro fertilization-embryo transfer in patients with polycystic ovarian syndrome will be discussed.

Abstract:

Mr Faraj is a consultant obstetrician and gynaecologist and has been in the speciality for the last 20 years. Mr Faraj is the lead of infertility Unit in Rotherham/South Yorkshire and had a wide experience in the management of infertile couples. He has a special interest in recurrent miscarriage, gynaecology scanning, endometriosis and Polycystic Ovary Syndrome. He was the medical director of the first IVF unit in Muscat and had the first IVF baby in the Sultanate of Oman.  Mr Faraj is also Senior Clinical Lecturer (Honorary) – University of Sheffield

Biography:

Johannes Ott has completed his PhD at the age of 30 years from postdoctoral studies at the Medical University of Vienna. He is a member of the Clinical Division of Gynecologic Endocrinology and Reproductive Medicine of the Medical University of Vienna. He serves as the “secretary” of the Austrian Society for Sterility, Fertility and Endocrinology. He has published more than 40 articles as first or senior author in reputed journals

Abstract:

Only about 70-80% of Clomifen-resistant women with polycystic ovary syndrome (PCOS) respond to laparoscopic ovarian drilling (LOD). Intraoperative hormone kinetics have been implemented in other surgical fiels including thyroid and parathyroid surgery. In a prospective study, we included 21 anovulatory women with clomiphene-citrate-resistant PCOS who underwent LOD and tested intra- and postoperative androstenedione levels as well as whether an intraoperative androstenedione change was predictive for spontaneous ovulation. Spontaneous ovulation, as the major outcome parameter, occurred in 15 women (71.4%) within three months after the operation. There was an intraoperative androstenedione decrease (median 3.5, IQR 2.2-4.8 vs. median 2.6, IQR 1.4-2.6 ng/ml, p=0.002). In multivariate analysis, only higher preoperative androstenedione (odds ratio, OR 6.53) and luteinizing hormone levels (OR 7.31), as well as secondary infertility (OR 5.40), were associated with higher rates of postoperative spontaneous ovulation (p<0.001). Thus, androstendione declined significantly during LOD. However, intraoperative kinetics were not useful for the prediction of spontaneous ovulation after LOD. In addition to these new results an overview on the literature about predictive factors for fertility outcome after LOD will be given in the presentation.

Biography:

Dr. Qin has completed his M.D. and PhD. from West China Medical Science College of Sichuan University. And he has finished his postdoctoral studies from Reproductive Medical Centre, Groningen University, Netherlands.  He has been worked for the most famous Reproductive Medical Centre for IVF-ET in West Area of China for 16 years. He is identified as Youth Member of Reproductive Medical, Gynecologic Endocrinology and Gynecologic Oncology in China. He awarded some important Scientific Fundus of China. He has published more than 15 papers in reputed journals and has been serving as a reviewer of some of them

Abstract:

Objective:  Immune  dysregulation  may  play  an  important  role  in  the  pathogenesis  of  polycystic  ovary syndrome  (PCOS).  The  purpose  of  this  study  was  to  investigate  the  Th1  and  Th2-related  cytokine  profile in  local  ovary  of  women  with  PCOS.

Study  Design:  The  T  lymphocytes  of  follicular  fluid  (FF)  were  obtained  at  the  time  of  oocyte  retrieval before  in-vitro  fertilization  (IVF)  in  woman  with  or  without  PCOS.  After  culturing  with  PMA,  Ionomycin and  Golgi  stop  agent,  cells  were  detected  for  the  intracellular  cytokine production  by  flow  cytometry.  The profile  of  Th1  (IFN-g,  IL-2)  and  Th2  (IL-4,  IL-10)  cytokines  of  CD3⁺CD4⁺ T  lymphocyte  subsets  were analyzed  through  invert  gating.  These cytokines  in  FF  were  also  evaluated  by  ELISA.

Results:  Flow  cytometry  analysis  showed  that  the  production  of  Th1  (IFN-g,  IL-2)  cytokines  in  FF lymphocytes  in  PCOS  patients  were  significantly  higher  than  those  in  controls;  ELISA  result  also demonstrated  that  the  concentration  of  Th1  cytokines  (IFN-γ,  IL-2)  in  FF  in  PCOS  patients  is  significantly increased  compared  with  those  in  controls.

Conclusion:  It  is  concluded  that  the  immune  dominance  of  Th1  may  be  the  immunological  feature  of  the ovary  in  PCOS  patients.  It  might  participate  in  the  immune  pathogenesis  in  the  ovary  of  PCOS  patients. These  results  suggest  that  chronic  inflammation  maybe  one  of  the  underlying  mechanism  for  the pathogenesis  of  PCOS

Biography:

Xu Wenming has completed his PhD (Physiology) in 2008 from The Chinese University of Hong Kong, Hong Kong and he got postdoctoral training from Columbia University School of Medicine. He is the principle investigator of Joint Lab for Reproductive Medicine, Sichuan University-The Chinese University of Hong Kong, in West China Second University Hospital. He has published more than thirty papers in reputed journals such as PNAS, Journal of Cell Science, Fertility&Sterility,et,al. and has been granted several awards such as First award of International Symposium on Frontiers in Life Sciences 2008. His major interests are epigenetic regulations of reproduction and reproductive diseases

Abstract:

miRNAs are important regulators of glucose metabolism and oxidative stress, which play key roles in the pathogenesis of PCOS. The objective was to study the expression of miRNA biogenesis related genes, including Dicer1, Ago2 and miR-15b and miR-503 in adipose of PCOS and normal controls, and further investigate the relationship of dysregulation of miRNA level with key parameters related to insulin resistance and oxidative stress in tissue level. PCOS patients and normal controls submitted to laparoscopic surgery were included, and adipose tissue and serum samples were collected. Our result shows that significantly reduced expression of Dicer1 were detected in adipose of PCOS patients. Correlation analysis indicated that miR-15b expression is positively correlated with Glut4 expression, while negatively correlatived with T-SOD. Our study also shows that follicular fluid contains microvesicle, which express Dicer proteins and could mediate the effects on phenotype of cumulus cells in ovary. Our result shows that dysregulation of miRNA biogenesis is related to the adipose insulin resistance and oxidative stress, and miR-15/16 famlily members, such as miR-15b is critical important for the insulin resistance and oxidative stress through targeting Glut4 pathway, thus represent a promising target of PCOS diagnosis and therapy.  

Biography:

Xiaomiao Zhao, MD.,Ph.D., an associate professor and associate chief physician of reproductive endocrine and advisor of Ph.D candidate, the vice president of Youth Committee of the Chinese OB/GT Committee of International Health Care Exchange and Promotive society. She has completed her M.D. at the age of 24 years and Ph.D at 30 years from Sun Yat-Sen University in Guangzhou, China and postdoctoral studies from Cedars-sinai medical center, University of California in Los Angeles, USA. She has published more than 45 papers, among which, over 19 papers in reputed English journals (e.g. Fertility and Sterility, Clinical Endocrinology, International of Caner, and International Journal of Cardiology, etc.) and serving as reviewer of International Journal of Cancer, JCEM and endocrinology. She takes charge of11 research grants of China.

Abstract:

This study is to investigate the distribution and progression of terminal hair growth in pregnant women and determine whether a simplified scoring system for assessing hirsutism was possible. We recruited 115 pregnant women (discovery cohort) from before pregnancy to 24^th gestation weeks and 1159 PCOS women (validation cohort) in out-patient department in an academic hospital and collected their clinical data including the assessment of facial and body terminal hair growth by modified Ferriman and Gallwey score system (mFG score) and the measurement of total testosterone (TT) level by liquid chromatographic tandem mass spectrometry (LC-MS/MS), through a prospective follow-up observational study. It showed that the TT level and mFG score increased as pregnancy progressing. Both the prospective study and receiver operating characteristics curve (ROC) indicated that the most contributive areas to hirsutism (defined as an mFG score ³ 5) with new terminal hair growth were upper lip, lower back, lower abdomen and thigh. From which, a simplified mFG scoring system (sFG) was developed and a cut-off value of ³3 was determined as ‘hirsutism’. The pregnant ‘hirsute’ women could be distinguished from ‘non-hirsute’ with an accuracy of 95.2%, sensitivity of 96.8% and specificity of 94.3% for detecting hirsutism. This was further validated in PCOS population with a sensitivity, specificity and PPV of 97.6%, 96.4% and 96.4%, respectively. This study suggests that upper lip, lower back, lower abdomen and thigh may be an effective simplified combination of the mFG system for the evaluation of excess hair growth in Chinese women.

Biography:

Alejandro Aldape Arellano has completed his physician and gynecologist studies in Monterrey, México. He has 7 years experience as Assisted Reproduction specialist. Performing in international centers such as: Vall d'Hebron University Hospital, Barcelona Marqués Institute. He has extensive experience developing guidelines and protocols in order to optimize pharmaceutical and biological resources. He implemented European guidelines of Assisted Reproduction in "La Paz" Medical Center in Malabo, Equatorial Guinea. He is currently the director of Ovocic a startup that developed an application for monitoring Assisted Reproduction cycles. He is also member of Spanish Fertility Society since 2010.

Abstract:

Poly Cystic Ovarian Syndrome (PCOS) is one of the most common metabolic and reproductive disorders among women of reproductive age. According to National Institute of Health (NIH) the prevalence is around 4-10%. Nowadays lifestyle changes such as exercise and calorie-restricted diet seems to be cost-effective excellent option considering that up to 76% of diseased woman present obesity. There is no discussion about effectiveness of clomiphene citrate (CC) as first line treatment of anovulatory infertility; however, we do not have a clear protocol of drugs when there is comorbidity (insulin resistance, high adrenal androgen, hyperprolactinemia). Therefore a complete evaluation and individualized treatment is mandatory. Second line treatments include ovulation induction with gonadotropins and laparoscopic ovarian drilling (LOD) most studies granted in general terms same results with some concerns about multiple pregnancy and ovarian hyperstimulation syndrome (OHSS) on the gonadotropin arm and premature ovarian failure (POF) on LOD arm. Anyway, whether we consider a first or second line therapy we cannot forget that the main problem in women of reproductive age is infertility therefore it is not just and individual problem but couple. A fertility approach means making an evaluation and diagnosis of both partners because only then we will know if the proposed algorithm remains in effect for a particular couple.       

Biography:

Dr. Dalida Omar Badla has completed her MD at the age of 26 years from University of Aleppo, Syria. She is the director of Obstetric and Gynecology Department at Almazroui Medical Center, One Day Surgery in Abu Dhabi, UAE.

Abstract:

Polycystic ovary syndrome (PCOS) is a heterogeneous familial disorder characterized by chronic anovulation and hyperandrogenism (clinical and/or biochemical). This multi-system, polygenic, multi-factorial disorder is associated with an increased risk for metabolic abnormalities such as type 2 diabetes mellitus. Signs and symptoms of PCOS often emerge during the peri-pubertal years with premature pubarche being the earliest manifestation for some girls. Central obesity, Insulin resistance and hyperinsulinemia are important pathophysiological features that are common to both premature pubarche and PCOS. Increasing evidence suggests that PCOS arises as a complex trait with contributions from both heritable and nonheritable factors. Polycystic ovaries appear to be transmitted as a dominant trait, usually asymptomatic but often accompanied by a subclinical PCOS type of ovarian dysfunction. Risk factors such as premature pubarche, obesity, ethnicity, and family history may be helpful. The evaluation of the adolescent with suspected hyperandrogenism or PCOS must be individualized depending on the symptoms and examination findings. Treatment must be individualized, too, and often requires a multidisciplinary approach.

Biography:

Asem Anwar has completed his combined supervised MD thesis from both Alazhar School of Medicine and Glasgow Universities. He is working as a Professor of Obstetrics and Gynecology at Alazhar School of Medicine since 2002 and Ex Director of the maternity university hospital [Syed Galal] Cairo-Egypt. He is the Secretary General of the Egyptian society for population reproductive health studies, Secretary General of the Healthy Child Healthy Mother Association and Consultant of ob/gyn at Air Force Specialized Hospital.

Abstract:

Aim: To compare between the effects of clomiphene citrate, tamoxifen and letrozole as ovulation induction agents on endometrial thickness and blood flow in women with polycystic ovaries.

Patients & Methods: One hundred and fifty cases meeting the selection criteria were prospectively randomized into 3 groups group 1 received 100 mg clomiphene citrate, group 2 received 5 mg letrozole and group 3 received 40 mg tamoxifen. Transvaginal ultrasound and Doppler were done to measure endometrial thickness and endometrial blood flow both pulsatility index (PI) and resistance index (RI) at the day of the maximum follicular growth or at day 20 in the absence of the dominant follicle in the 3 groups.

Results: Significantly thinner endometrium in the clomiphene citrate group as compared to the other two groups and lower impedance in the spiral arteries in both letrozole and tamoxifen groups were found (P value less than 0.001).

Conclusion: Endometrium was thicker with lower impedance in the spiral arteries in both letrozole and tamoxifen groups as compared to clomiphene citrate group. Ovulation and pregnancy rates were not significantly different. Further studies are needed to measure the cumulative results of 6 cycles, increasing the dose in non-responders and the incidence of miscarriage.

Biography:

Lisa Morrissey completed his BSc at the age of 21 from Maynooth University in Dublin, Ireland and from there went on to study the discipline of Traditional Chinese Medicine and Acupuncture. Lisa has a fascination with natural healing and has also trained as a Shaman’s apprentice, studied Chakra Balancing in Thailand and lived with the Monks in Thailand for a period of time, practicing Vipassana, learning the art of silent meditation. Lisa is currently the director of Baby Steps, a natural fertility and pregnancy clinic and is in the process of opening her own health retreat centre.

Abstract:

From a Traditional Chinese Medicine perspective we look at the individual presentation of each patient. PCOS wouldn’t be considered under one generic pattern or diagnosis. The diagnosis and treatment will be specific to the individual presentation. However acupuncture alone isn’t enough to treat PCOS, there isn’t a magic bullet fix, you need to be open to healing. Regardless of what route the individual chooses to go, to choose Western Medicine and take Metformin or similar or to choose Traditional Chinese Medicine, the most important change needed is mindset and belief. You need to ground yourself and open your body up to healing. You need to love your PCOS and accept it. You may recognize yourself going through the Kübler-Ross 5 stages of grief – denial, anger, bargaining, depression and acceptance. When you open yourself to acceptance and healing you will see all of the healing possibilities around you that you were not able to see before. If you feel like a victim your mind will look for things to prove you right and you won’t see the health solutions. You will have thought you tried everything but if you really question it, have you? Now you can really change your diet with discipline to a healthier diet and to lose weight if needs be. Now you will walk in nature and meditate daily. If you don’t really believe then you won’t have the willpower to do what needs to be done to truly heal.

Biography:

Amany A Salama has completed her Master degree (OB/GYN) 1989, Faculty of Medicine, Alexandria University. Then slightly shifted to study nutrition and its application to women’s health and completed her PhD in Public Health (Nutrition) 2014, High Institute of Public Health, Alexandria University. Works as a Consultant of Women’s Health and Nutrition at Madina Women’s Hospital, Alexandria, Egypt, and a lecturer of clinical nutrition, Faculty of Allied Medical Sciences - Pharos University in Alexandria. Academic research interests: Nutrition – Inflammation - Polycystic ovary syndrome – Oncology.

Abstract:

Polycystic ovary syndrome (PCOS) is a common endocrine disorder with diverse reproductive and metabolic features. Obesity is highly prevalent in the general population and in PCOS women and is an independent risk factor for cardiovascular disease. The study was to investigate the effect of anti-inflammatory diet - in the context of lifestyle modification - with or without the use of metformin in overweight and obese women with PCOS. Out of 220 adult overweight and obese females with PCOS, 150 completed the trial, 75 in each group. Pre and post study fasting blood samples measured biological markers and body composition was assessed by the InBody720. Participants were subjected to either lifestyle interventions with an anti-inflammatory dietary combo and physical activity alone (LS-ONLY) for 12 weeks or with the added use of Metformin 850 mg twice daily (LS+MET). Both strategies achieved moderate weight loss of (±7%) and significant improvements in body composition, hormones and menstrual cyclicity, blood pressure, glucose homeostasis, dyslipidemia, C-reactive protein and serum amyloid A (surrogate measures of cardiovascular risk (CVR)). A 63% regain of menstrual cyclicity and 12% spontaneous pregnancy rate within 12 weeks were achieved. We have found that in overweight and obese women with PCOS, adding metformin to lifestyle modifications at a dose of 850 mg twice daily, had no superior effect to lifestyle modifications alone on; menstrual frequency, pregnancy rates, weight loss, reduction of insulin resistance or reduction of hyperandrogenism. An anti-inflammatory dietary approach with pharmacological targeting can achieve a clinically relevant weight loss in PCOS patients.

Biography:

Abstract:

A negative significant correlation was found between the level of E2 and the age, and between E2 and the weight of patients. Also the testosterone level was correlated significantly and positively with the level of FSH.

Conclusion: the genes identified in this study may play an essential role in the pathogenicity of ovarian hyperstimulation syndrome. Also serum VEGF concentrations may predict OHSS occurrence.

Biography:

Anita Mani is a renowned Infertility Specialist in South India with 15 years of experience in ART (Assisted Reproductive Technology). She completed her MRCOG from Royal College of Obstetrician and Gynecologist, London and worked in UK for 5 years before returning to India to establish GIFT IVF centers. PCOS awareness among teenagers and young women is her special interest. An integrated PCOS clinic has been established with counselors, dietician and physical trainers at GIFT IVF center.

Abstract:

The clinical symptoms of PCOS in teenagers often overlap with the normal development, making it difficult to diagnose the condition. The symptoms like irregular periods can be found in normal adolescents, as it takes a few years for hypothalamo-pituatory axis to become mature after menarche. Acne is a sign of hyperandrogenism, but it is found in 80% teenagers and hence not specific for PCOS. Hirsutism is related to the duration of exposure of androgens, and becomes marked towards adulthood. The third criteria as per Rotterdam criteria of polycystic ovaries on scan can be missed on a trans-abdominal scan, especially in obese girls. Teenagers can have multi cystic ovaries without PCOS. The intake of contraceptive pills can mask the symptoms. General reluctance towards a consultation at that age can often delay the diagnosis; especially as they are prone to social isolation, anxiety and depression in addition to mood variations and irritability. Weight loss is well known as the most difficult target due the hormonal abnormalities. Motivating obese girls to lose weight takes professional help, targeted behavioral change techniques, which is not widely practiced. Dietary changes and regularity of food intake are difficult to impose on young girls. The most important aspect is counseling, and is very much lacking in the current management. Risks of metabolic sequelae are often overlooked.

Biography:

Svetlana Colovic graduated from Belgrade Medical School in 1994. She did her Residency in OBGY in 2001 at Belgrade University Clinic. She has been working in Health Care Institute for University Student since 2007; and is also doing her private OBGY practice. She attended Women’s Health Program CA, USA in 2010. She is active Member and Reviewer of European Society for Reproductive Health, Member of Consortium for Urgent Contraception NY, USA, and is part of UNICEF and USAID program for opening counseling in Serbia.

Abstract:

Background: Reproductive and sexual health is an important aspect of quality of life. PCOS is complex endocrine condition, being recognized as impacting students in Serbia and world at much greater degree than previously thought. The clinical and biochemical presentation is heterogeneous, but elevated serum concentrate of androgens are the most consistent biochemical abnormality. High percentages of women have insulin resistance and ultrasound picture of PCO. The most concern for students with PCOS is signs of obesity, hirsutism, acne, loss of hair, etc. Reviewing about 10,000 students of Belgrade University with PCOS during last 10 years, average 5 per day, age 17 to 26 showed importance of early diagnosis and early treatment as the best way to protect reproductive health.

Methods: Descriptive correlation research design is conducted in Women’s Department, Health Care Institute for University Students Belgrade, Serbia. Data was collected from 1000 female students for last 5 years with PCOS, with or without medical or alternative treatment, in the form of questionnaires plus gynecological and ultrasound exam by myself.

Results: The result showed that the most of the study of the sample (>60%) have negative implicate on quality of life (social, sexual, self-respect, etc.). Women with PCOS without treatment (medical or alternative) were 94%. Women with PCOS with treatment (medical or alternative) were 30%.

Conclusion: Importance of early diagnosis especially subclinical forms of PCOS, early diagnosis and appropriate treatment as crucial thing in prevention and improvement of reproductive health, good quality of life, sexual health, self-confidence and self-respect of Belgrade students and young people at all is concluded.

Biography:

Dr. Gersh is one of only a small number of fellowship trained integrative, Board Certified gynecologists in the nation. She blends the best of the world of natural and holistic medicine with state of the art functional and allopathic medical treatments, creating the greatest chance for women to maintain and regain their health. Because of her extensive knowledge of the complex inter-relationships of the body's organs, she recognizes the need to investigate all aspects of health, always working to re-establish a healthy gastrointestinal tract, evaluate and eliminate environmental toxicants, ensure adequate sleep, good mood, great nutrition, high energy, and balanced hormones.

Abstract:

The human body is not what it was once thought to be... in actuality it is a super-organism. The bacteria and viruses within and on our bodies are critically important to maintaining our well- being, including all aspects of our metabolic and reproductive functions!! The microbiome works in an amazingly synergistic manner to maintain our homeostasis. The bacterial genetic material within the gastrointestinal tract, called the gut microbiome, has now been identified as a vital component of our existence. Research is now showing that an altered hormonal milieu, combined with an unhealthy diet, is likely a major component of the PCOS epidemic, stemming from the alterations occurring to the gut microbiome. Working with diet to modify the gut microbiota is therefore a key part of the treatment of PCOS. This presentation will review the basics of the gut microbiome, how it is developed, and how dietary choices can impact the microbiome to reduce the severity of PCOS symptoms and their negative health impact.

Biography:

Dr. Shelmire is a graduate of National University of Health Sciences, IL. She is one of five Naturopathic Physicians in Louisiana. She uses several modalities including Botanicals, Homeopathy, Hydrotherapy, Nutrition and supplements, Lifestyle and psychological counseling, physical manipulation skills, Minor surgery, and Modern diagnostic and laboratory testing. She owns her own private practice, Alternative Natural Health Solutions, LLC. She is the Naturopathic writer for BlackDoctor.org, and has been featured on the podcast series Black People Speak, The Dr. Krystal Shelmire Episode. Dr. Shelmire has also been featured on KLFY News discussing Life hacks to help with migraines and headaches.

Abstract:

Naturopathic medicine focuses on treating the root cause of disease, not just treating the signs and symptoms. Treating a patient with PCOS using naturopathic medicine would mean that the physician is taking a very detailed history to obtain the totality of symptoms and therefore treating the person as individual, not simply treating the disease. Symptoms that the patient may think are unrelated to PCOS could in fact be the key factors that help to determine the root cause. Naturopathic physicians use a series of seven steps called the Therapeutic Order to devise a treatment plan for patients, similar to how scientists use the scientific method to prove hypotheses. A brief introduction into naturopathic medicine as well as a detailed walk through the seven steps of the naturopathic therapeutic order will demonstrate possible treatment plans for typical PCOS patients. Each patient is unique and a visit to a naturopathic physician would yield a more individualized treatment plan to treat the totality of symptoms, and to treat the whole person, not just the disease.

Biography:

Robert Tygenhof completed his A.B. degree at Princeton University and his M.A. at the University of Southern California. He received his Fitness Specialist certification from Irvine Valley College, is certified as a Personal Trainer by the American College of Sports Medicine, and has served for the past five years as the Director of the Center for Active Lifestyle Medicine at the Integrative Medical Group of Irvine in California.

Abstract:

Exercise has been shown over and over again to have a profound effect in reducing systemic inflammation and lowering oxidative stress. Consequently, it is routinely recommended as part of the lifestyle treatment plan for PCOS women, whether they are overweight/obese or not. But it may not be quite that simple; rarely are the following questions asked, even though they have a profound bearing on the effectiveness of the overall program:

• How much exercise is enough? There’s no point in prescribing too little to be effective or more than is necessary.
• How much exercise is too much? Can you actually recommend – or can your patient self-prescribe – so much exercise that the benefits begin to decline and are outweighed by the harm incurred?
• What are the latest technologies for measuring the body composition effects of exercise? Wouldn’t it be nice to know with some degree of precision how effective a program is for your patients?

You will also find out how exercise intensity impacts effectiveness and you will learn about the latest data on High Intensity Interval Training – is compliance better or worse than it is for long, slow exercise and are the benefits actually worth the extra effort and risk?

Biography:

Victoria Miles made the decision to retrain at the age of 28 and has since dedicated vast amounts of time to research and case studying to develop her clinical expertise to its current level. Clinically qualified she specialised in fertility and pregnancy. She has had the privilege of working with clients from all over Europe and has published much of her work through blogs and articles.

In 2015 a number of UK based national newspapers wrote articles on her dedication to her work. With over 300 babies now born through Baby Farm treatment plans she is thrilled to see many couples come back for second and third rounds of treatment. The business is In the early stages of being franchised and the book The Baby Farm Way is in its completion stage. Following book number one will be a book dedicated to IVF, a meal plan book and an educational book designed to feed into schools to encourage teenagers to think towards their fertility future.

Abstract:

A natural fertility treatment company that is dedicated to educating, training and supporting individuals throughout their fertility journey. Specialising in pcos, endometriosis, multiple miscarriage, hormone imbalance (male and female), unexplained infertility, still birth, pregnancy and birth. Working with both private clients and clients receiving NHS (free healthcare) fertility treatment, private IVF clinic clients and also works on a consultant basis by agreement with private fertility clinics. The success rate for natural treatment clients who commit to and complete a full treatment plan is 100% for those who use Baby Farm as a support to aid IVF and commit to, and complete a plan the success rate is over 80%. 50% of the IVF clients have pcos.

A treatment plan will involve lifestyle changes, including nutrition and exercise and also intensive stress management. It will also use holistic therapies, primarily reflexology due to its effective and fast results. In terms of pcos the majority of clients will undergo treatment plans that typically last in excess of 6 months. This tends to be down to the need to make quite excessive lifestyle changes that clients need time to settle into. Baby Farm also works with clients through their pregnancy to ensure things run smoothly from start to finish.

Biography:

Dr. Taher H. Khalil, is a Fellow of American College of Endocrinology since 1998. He graduated from Faculty of Medicine, Alexandria University, Egypt in 1969 and completed his post graduate

M.D. Thesis in collaboration with U.S. Office of Naval Research, Arlington, Virginia in 1979. He is Director of Hormonal Disorders Specialty in Dubai since 1995. Dr Khalil is involved in management of PCO since 1973 and in combining laser treatments from 1997. He co-founded and directed Sharjah University Laser Training and Research Center since 2010. He published more than 15 scientific publications in major journals and conferences since 1979.

Abstract:

Biography:

Abstract:

Background: In the last few years a growing interest in vitamin D can be observed in various segments of medical field due to findings demonstrating low vitamin D status in the population and its harmful effects on various systems. Vitamin D also plays a vital role in expression of a large number of genes in reproductive tissues implicating a role for vitamin D in female reproduction.

Objective: To evaluate the Vitamin D levels in infertile females to study the correlation of circulating 25-hydroxyvitamin D (25OH-D) levels with serum antimmullerian hormone in infertile females compare to fertile females.

Design: Prospective study was conducted in department of Maternal and Reproductive Health in between 2014-2016 for 2 years.

Patient(s): All infertile females as cases and fertile females as controls were taken after some inclusion and exclusion criteria. 35 patients were taken in each group.

Intervention(s): Serum for 25-hydroxyvitamin D (25OH-D) and AMH with other infertility investigations were taken.

Main Outcome Measure(s): Vitamin D levels in infertile females and correlation between 25OH-D and AMH in vitamin D deficient infertile and fertile females.

Result(s): On analysis of data the Vitamin D deficiency was present in 64% of infertile female’s population. In vitamin D deficient cases (infertile females) the mean for vitamin D was 6.18± 2.09 and for AMH 1.94±1.30. In vitamin D deficient controls (fertile females) the mean for vitamin D was 4.85±3.02 and for AMH 3.47±2.59. There is no significant correlation between vitamin D and AMH levels in these two groups. On comparison of these two groups Vitamin D levels were more lower in control group than cases which was significant (P=0.04) and AMH levels were more lower in cases than control group(P=0.003).

Conclusion(s): In this study, no significant correlation was found in between circulating Vitamin D and antimmullerian hormone levels.