Polycystic Ovarian Syndrome Conference

Biography

Biography: Ozgun Ozcaka

Abstract

Periodontal diseases, including gingivitis, are common chronic infectious diseases caused by predominantly pathogenic microorganisms that colonize the sub-gingival area and cause local and systemic elevations of pro-inflammatory cytokines resulting in tissue destruction. Gingival cervicular fluid (GCF) is regarded as a transudate enriched with dental microbial and host products that increases as a result of host–microbe interactions. Several lines of evidence established the association between periodontal and systemic diseases, including metabolic syndrome, diabetes, and CV disease. Because of the fact that both periodontal disease and metabolic syndrome are associated with systemic inflammation and insulin resistance, these two disorders may be linked through a common patho-physiologic pathway. PCOS appears to be associated with increased oxidative stress and systemic inflammation because females with PCOS have increased markers of lipid peroxidation, C-reactive protein, inflammatory cytokines and percentage of blood lymphocytes and monocytes. The causes of these alterations have not yet been identified, but chronic infections may induce inflammation and oxidative stress and possibly contribute to insulin resistance, ovarian dysfunction, and other characteristics of PCOS. It is the aim of this lecture to clarify the influence of gingival inflammation and GCF, saliva, serum concentrations of inflammatory cytokines and clinical periodontal findings in PCOS females and to answer the title question whether there is any association between PCOS and gingival inflammation.